Figure 5. Implication of known genomic alterations, variants of unknown significance (VUS), and their combination in activated pathways. Bars represent the known genomic alterations (A-D), possibly damaging VUS (B-E) or their combination (C-F) involved in the activated pathways reported in Figure 3 and generated by the DAVID (gray bars) or PANTHER (black bars) tools. The height of each bar varies according to the different rate of gene involvement in the different pathway. White columns in C and F panels indicate genes identified exclusively by the combination of known genomic alterations and possibly damaging VUS. The dashed line identifies the median rate gene involvement in the different pathways.