Table 1.
Clinical and molecular summary of the three case-control datasets
|
UCSF-Mayo cases N = 1,973 |
GICC controls N = 1,859 |
AGS i370 cases N = 659 |
AGS i370 controls N = 586 |
TCGA cases N = 786 |
WTCCC controls N = 5,711 |
|
|---|---|---|---|---|---|---|
| Age | ||||||
| <40 | 983 (50%) | 538 (29%) | 101 (15%) | 85 (15%) | 213 (27%) | 0 (0%) |
| 40–59 | 476 (24%) | 555 (30%) | 329 (50%) | 252 (43%) | 279 (36%) | 0 (0%) |
| ≥60 | 514 (26%) | 766 (41%) | 229 (35%) | 249 (42%) | 245 (31%) | 0 (0%) |
| Missing | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 49 (6%) | 5,711 (100%) |
| Sex | ||||||
| Female | 822 (42%) | 744 (40%) | 229 (35%) | 280 (48%) | 328 (42%) | 2,819 (49%) |
| Male | 1,151 (58%) | 1,115 (60%) | 430 (65%) | 306 (52%) | 458 (58%) | 2,892 (51%) |
| IDH mutation status | ||||||
| Mutant | 588 (30%) | N/A | 111 (17%) | N/A | 375 (48%) | N/A |
| Wild type | 699 (35%) | N/A | 416 (63%) | N/A | 364 (46%) | N/A |
| Missing | 686 (35%) | N/A | 132 (20%) | N/A | 47 (6%) | N/A |
| Molecular subtype based on IDH mutation and 1p/19q codeletion | ||||||
| MT-codel | 244 (12%) | N/A | 9 (1%) | N/A | 143 (18%) | N/A |
| MT-noncodel | 291 (15%) | N/A | 94 (14%) | N/A | 230 (29%) | N/A |
| WT-noncodel | 507 (26%) | N/A | 416 (63%) | N/A | 357 (46%) | N/A |
| Missing/other | 905 (47%) | N/A | 140 (22%) | N/A | 56 (7%) | N/A |
N/A, not applicable to controls.