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. 2022 Jul 1;23:175. doi: 10.1186/s12931-022-02097-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Rates of overall detection in the entire cohort or in specific patient subgroups. A Mutation detection rates of tumor tissue (TIS), sputum supernatant (SPU), and plasma (PLA) samples in all patients. Mutation detection rates of SPU among B patients with centrally vs. peripherally located lung tumors, C lung squamous cell carcinoma (LUSC) vs. lung adenocarcinoma (LUAD) patients, and D smokers vs. non-smokers. Comparison of detection rates of the three biopsy types in E and F patients with centrally or peripherally located lung tumors, respectively, G smokers, and I LUSC patients. Mutation detection rate was defined as the ratio of the number of samples detected with somatic mutations to the total number of samples of the same type. Numbers within the bars indicate the numbers of samples of the corresponding type, subgroup, and detection status