Table 3.
Interaction analyses of NFE2L2 SNPs*SHS in asthma risk.
| A. GCPCR study population. | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Minor/ Major allele |
MAF | All (n=669) | SHS (n=258) | No SHS (n=411) | SNP*SHS Interaction (n=669) |
||||
| OR1 (95% CI) |
P | OR (95% CI) |
P | OR (95% CI) |
P | OR (95% CI) |
P | |||
| rs10183914 | A/G | 0.360 | 1.02 (0.79,1.32) |
0.89 | 1.70 (1.03,2.90) |
0.04 | 0.84 (0.62,1.14) |
0.25 | 1.99 (1.11,3.65) |
0.02 |
| rs6726395 | A/G | 0.456 | 0.96 (0.75,1.22) |
0.74 | 1.35 (0.87,2.12) |
0.18 | 0.82 (0.61,1.10) |
0.19 | 1.63 (0.97, 2.77) |
0.07 |
| rs1806649 | A/G | 0.239 | 1.02 (0.77,1.37) |
0.88 | 2.09 (1.14,4.10) |
0.02 | 0.80 (0.57,1.12) |
0.20 | 2.55 (1.28, 5.34) |
0.01 |
| rs2886161 | G/A | 0.338 | 0.91 (0.69,1.18) |
0.46 | 0.58 (0.37,0.91) |
0.02 | 1.14 (0.82,1.59) |
0.44 | 0.51 (0.29,0.90) |
0.02 |
| B. GCC replication cohort. | ||||||||||
| SNP | Minor/ Major allele |
MAF | All (n=791) | SHS (n=157) | No SHS (n=634) | SNP*SHS interaction (791) |
||||
| OR (95% CI) |
P | OR (95% CI) |
P | OR (95% CI) |
P | OR (95% CI) |
P | |||
| rs10183914 | A/G | 0.36 | 0.88 (0.64,1.20) |
0.42 | 1.48 (0.74,2.96) |
0.27 | 0.73 (0.50,1.05) |
0.1 | 2.20 (1.02,4.76) |
0.04 |
| rs6726395 | A/G | 0.456 | 0.94 (0.69,1.27) |
0.68 | 1.22 (0.62,2.40) |
0.56 | 0.85 (0.60,1.20) |
0.36 | 1.55 (0.75,3.25) |
0.24 |
| rs1806649 | A/G | 0.239 | 1.06 (0.75,1.46) |
0.75 | 1.35 (0.67,2.63) |
0.39 | 0.96 (0.64,1.40) |
0.83 | 1.52 (0.69,3.27) |
0.29 |
1
Odds ratios (ORs) for life time asthma risk were obtained using logistic regression analysis. The models were adjusted for age and sex. ORs refer to increase in risk for each additional minor allele. Genotypes were coded as copy numbers of minor allele (additive/continuous).