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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Proc IEEE Int Conf Big Data. 2019 Jan 24;2018:1494–1503. doi: 10.1109/bigdata.2018.8622637

Fig. 6.

Fig. 6.

Scheme of the hypothesis of Stress-Granule dependent mechanism of neuroprotection by DDX3 inhibitor. Neurons are curved figures. Treatment with HIV-Tat leads to DDX3-dependent formation of SGs (A), which transform from “normal” to “pathological” (B). The addition of cocaine further enlarges the SGs and leads to the death of the neurons (C). Treatment with DDX3 specific inhibitor blocks DDX3 enzymatic activity and Tat-dependent SG formation (D) and protects the neurons from cocaine-induced death (E).