Figure 1.

A-D, Graphs show survival curves based on Kaplan-Meier analyses and receiver operating curves. Rows show analyses based on IL-6 (A), TNF-α (B), IL-8 (C), and NT-proBNP (D). The leftmost column shows analyses in BMPR2-mutation-positive patients; the middle column shows analyses in patients with PAH without mutations, and the rightmost column shows the ROC curve that enables a direct comparison in both groups of patients. For A-B, log-rank P values are shown. For C, the P values shown relate to the significance of the AUC compared with the “line of no discrimination.” For ease of reading, the BMPR-2 mutation data are presented in color, and the PAH without mutation data are presented in black. AUC = area under the curve; BMPR2 = bone morphogenetic protein receptor type-2; NT-proBNP = N-terminal pro-B type natriuretic peptide; PAH = pulmonary arterial hypertension; ROC = receiver operating characteristic; TNF = tumor necrosis factor;