Table 3.
Placental release and uptake. The ten proteins with the smallest FDR adjusted p-values
| Protein name | Entrez gene symbol | FDR adjusted p-value* | |
|---|---|---|---|
| Proteins released by the placenta to the maternal circulation | % higher RFU in uterine vein | ||
| Pleiotrophin | PTN | 7.57E−17 | 33.68 |
| Fatty-acid amide hydrolase 2 | FAAH2 | 2.90E−16 | 97.85 |
| Secreted frizzled-related protein 3 | FRZB | 2.90E−16 | 56.58 |
| Secreted frizzled-related protein 1 | SFRP1 | 2.90E−16 | 22.62 |
| Signal peptide, CUB and EGF-like domain-containing protein 3 | SCUBE3 | 4.08E−16 | 23.77 |
| Placenta growth factor | PGF | 1.17E−15 | 76.17 |
| Urokinase-type plasminogen activator | PLAU | 2.68E−14 | 55.37 |
| Tubulin polymerization-promoting protein family member 2 | TPPP2 | 2.49E−13 | 32.90 |
| Noggin | NOG | 2.49E−13 | 14.44 |
| Transgelin | TAGLN | 8.36E−13 | 38.39 |
| Proteins taken up by the placenta from the maternal circulation | % lower RFU in uterine vein | ||
| Beta-defensin 1 | DEFB1 | 3.14E−11 | 14.51 |
| Insulin | INS | 3.06E−07 | 6.53 |
| Parathyroid hormone | PTH | 5.95E−07 | 9.92 |
| Urokinase plasminogen activator surface receptor | PLAUR | 2.13E−06 | 6.19 |
| Corticotropin-releasing factor-binding protein | CRHBP | 7.53E−05 | 5.60 |
| Trefoil factor 2 | TFF2 | 8.12E−05 | 5.41 |
| Vascular endothelial growth factor A, isoform 121 | VEGFA | 1.11E−04 | 4.19 |
| Trefoil factor 1 | TFF1 | 1.89E−04 | 6.09 |
| Steroidogenic acute regulatory protein, mitochondrial | STAR | 2.10E−04 | 6.25 |
| Complexin-2 | CPLX2 | 2.40E−04 | 3.05 |
*Paired t-tests of log 2 RFU venoarterial difference using Benjamini-Hochberg false discovery rate