Fig. 7.

Soluble αS oligomers detected by Syn33 are not affected by tau expression. a Dot blot detection of human αS (LB509), αS off-pathway oligomers (Syn33), and total αS (4D6) in buffer-soluble spinal cord fractions of 70-dpi and end-stage mice. b No differences in LB509 or Syn33 were observed as a result of tau expression. c, d Syn33+ αS oligomers were not detected in the detergent-insoluble spinal cord fractions of both 70-dpi and end-stage mice. Abbreviations: days post inoculation, dpi; end stage, ES; arbitrary units, A.U.; n = 4–5 animals/genotype; error bars represent mean ± SEM