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. Author manuscript; available in PMC: 2022 Sep 14.
Published in final edited form as: Nat Chem Biol. 2022 Mar 14;18(5):511–519. doi: 10.1038/s41589-022-00981-0

Extended Data Fig. 8. SV-AUC c(s) analysis of insulin analogs.

Extended Data Fig. 8

a, DOI (des octapeptide insulin) and hIns (human insulin) controls at a concentration of 100 μg/ml and 775 μg/ml respectively in phosphate buffer (137 mM NaCl, 2.7 mM KCl, 5.3 mM Na2HPO4, 1.8 mM KH2PO4, pH 7.4). b, Vh-Ins-HSLQ and Lispro both at 500 μg/ml in sterile insulin diluent (16 mg/ml glycerol, 1.6 mg/ml m-cresol, 0.65 mg/ml phenol, 3.8 mg/ml Na2HPO4, pH 7.4). c-d, Data fit and residuals for DOI, hIns, Vh-Ins-HSLQ and lispro, respectively. For clarity, some scans are omitted from the figures shown but all scans were used for the c(s) analysis. The interval between the scans shown in each panel is ~9 minutes.