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Density is shown around Vh-Ins-HSLQ. Vh-Ins-HSLQ green, with Vh-Ins mutated residues relative to native human insulin shown in orange. Receptor FnIII-1 domain, purple. The only Vh-specific residue that approaches receptor at site 2 is GluB10, which has poor density. Nearby receptor side chains lack density but are shown explicitly for illustrative purposes.
