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. 2022 Jun 17;12:881022. doi: 10.3389/fonc.2022.881022

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Copyright © 2022 Wang, Wang, Li, Niu, Liang, Liu, Liu and Ge

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic model of ELFN1-AS1 functions in tumor progression. ELFN1-AS1 could sponge miR-138-5p and miR-1291 to promote macrophage M2 polarization in macrophages via CREB1 upregulation, which in return promote OS progression.