FIGURE 1.

The pipeline for the landmark‐guided region‐based spatial normalization (LG‐RBSN) solution. Subject's T1 image is processed with FreeSurfer for surface reconstruction and parcellation. Then, an automatic regional landmark extraction and matching approach (Section 2.1) is used to extract regional landmarks from the results of surface registration. For each region independently, the landmark‐guided large deformation diffeomorphic registration (Section 2.2) is performed resulting in a distinct displacement field for that region. We then combine the regional displacement fields together using a novel interpolation technique (Section 2.3) to give a single global displacement field for the whole brain. Finally, a residual compensation approach is used to enforce bijectivity property into the global deformation field (Section 2.4)