FIGURE 4.

Comparison of ANTs and LG‐RBSN registration results in cortical gyrus registration simulations with cases of moving and fixed images (a) aligned initially and (b) mis‐aligned initially. In experiment (a), ANTs matched the whole gyrus mask perfectly but failed to accurately align the underlying three regions (yellow and green arrows mark the same location across images). In experiment (b), ANTs fell into a local minimum and failed to match even the binary mask of the entire gyrus. LG‐RBSN matched the whole structure mask and regions perfectly in both experiments. ANTs, advanced normalization tools; LG‐RBSN, landmark‐guided region‐based spatial normalization