FIGURE 8.

DSC comparison between affine, ANTs, CVS, and LG‐RBSN. LG‐RBSN shows significantly higher DSC in matching brain cortical regions, sub‐cortical regions, and cerebral WM than ANTs. LG‐RBSN shows significantly higher DSC in matching brain cortical regions and cerebral WM than CVS. And LG‐RBSN is more robust working with both young and older subjects compared to ANTs and CVS, as LG‐RBSN shows less variance of DSC in matching brain cortical regions and cerebral WM. ANTs: advanced normalization tools; CVS: combined volumetric and surface registration; DSC: dice similarity coefficient; LG‐RBSN: landmark‐guided region‐based spatial normalization; WM, white matter