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. 2022 Jun 28;39(13-14):979–998. doi: 10.1089/neu.2022.0012

FIG. 2.

FIG. 2.

Pediatric traumatic brain injury (TBI) impairs long-term potentiation (LTP) in the dorsal hippocampus. LTP was measured in the CA1 region of the dorsal hippocampus of sham and brain-injured animals (n = 11 sham slices, 10 injured slices). (A) Representative excitatory field post-synaptic potentials (EPSP) traces demonstrating input/output responses in the CA1 region. (B) The amplitude of field EPSPs (fEPSPs) in response to varying levels of stimulation in sham and brain-injured slices. (C) Representative fEPSP traces demonstrating amplitudes at baseline, 10 min, and 60 min following theta-burst stimulation. (D) The average fEPSP amplitude (displayed as percent of baseline values) during the 20-min baseline recording and 60-min post-stimulation recording period. (E) The fEPSP amplitude averaged at 10 min or 60 min following theta-burst stimulation in sham and brain-injured animals. Bars represent group mean values and error bars represent standard error of the mean. HFS, high frequency stimulation. *p < 0.05.