TABLE 1.
Subject demographics. Group averages and standard deviations are given.
| Healthy controls | ACTL patients | SCD patients | |
|---|---|---|---|
| N | 24 | 17 | 25 |
| Age | 27.3 ± 8.2 | 21.6 ± 5.6 | 24.1 ± 6.8 |
| Sex | 11F, 13M | 10F, 7M | 11F, 14M |
| Hematocrit (%) | 40.8 ± 4.1 | 35.2 ± 5.9* | 26.8 ± 4.3*δ |
| Hemoglobin (g/dl) | 13.6 ± 1.4 | 11.5 ± 2.8* | 9.5 ± 1.7*δ |
| HbS (%) | 12.4 ± 17.5 | 2.5 ± 10.2 | 67.8 ± 25.2*δ |
| HbF (%) | 0 | 4.5 ± 6.0* | 12.1 ± 10.5*δ |
| Systolic blood pressure (mmHg) | 114.7 ± 9.0 | 115.2 ± 11.5 | 114.0 ± 10.0 |
| Diastolic blood pressure (mmHg) | 69.0 ± 7.5 | 62.1 ± 8.1* | 61 ± 6.3* |
| Oxygen Saturation (%) | 99.1 ± 1.2 | 99.2 ± 1.0 | 98.6 ± 1.4 |
| O2 content (ml O2/ml blood) | 18.5 ± 1.9 | 15.6 ± 3.8* | 12.9 ± 2.4*δ |
| Lactose dehydrogenase (LDH) | 548.2 ± 86.4 | 635.2 ± 250.0 | 863.0 ± 432.2*δ |
| MCV (cubic um/red cell) | 85.5 ± 7.4 | 79.5 ± 9.7 | 96.1 ± 16.6*δ |
| MCH (pg/cell) | 28.8 ± 2.6 | 25.8 ± 5.3* | 34.0 ± 6.7*δ |
| MCHC (g Hgb/dl) | 33.4 ± 1.3 | 31.7 ± 4.1 | 35.2 ± 1.6*δ |
| Reticulocytes (%) | 1.5 ± 0.7 | 3.6 ± 3.4* | 8.4 ± 4.9*δ |
| Transfused | 0/24 | 7/17* | 4/25 |
*Denotes p < 0.05 with respect to control, δ denotes p < 0.05 with respect to ACTL.