Table 2.
Frequency of Molecular Alteration in Select Genes in Cohort
| Gene | Total (%) |
|---|---|
| TERT promoter (N = 283) | 180 (63.6) |
| CDKN2A | 254 (45.6) |
| CDKN2B | 229 (41.1) |
| PTEN | 196 (35.2) |
| EGFR amplification | 186 (33.4) |
| TP53 | 161 (28.9) |
| MTAP (N = 283) | 108 (38.2) |
| CDK4 | 61 (11.0) |
| NF1 | 54 (9.7) |
| PIK3CA | 51 (9.2) |
| PDGFRA | 43 (7.7) |
| RB1 | 41 (7.4) |
| MDM2 | 36 (6.5) |
| MDM4 | 31 (5.6) |
| PIK3C2B | 31 (5.6) |
| PIK3R1 | 21 (3.8) |
| STAG2 | 16 (2.9) |
| ATRX | 14 (2.5) |
| BRAF V600E | 12 (2.2) |
| PTPN11 | 7 (1.3) |
| NOTCH1 | 3 (0.5) |
| POLE (N = 283) | 2 (0.7) |
| APC | 2 (0.4) |
| SETD2 | 1 (0.2) |