Fig. 6.

Single-cell transcriptomics of primary and recurrent tumors. (A, B) UMAP plots and heatmaps depicting clustering of tumor cells from primary and recurrent xenografts. (C) Gene expression overlap between clusters. (D) Single-cell expression levels of selected genes in primary vs recurrent tumors. (E) Graphical summary of the iatrogenic induction of PTN-mediated self-renewal and proliferation in glioblastoma recurrences. Abbreviations: PTN, pleiotrophin; UMAP, uniform manifold approximation and projection.