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. 2022 Jun 17;12:908247. doi: 10.3389/fonc.2022.908247

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Copyright © 2022 Tucker and Degen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The images to the left show double label immunohistochemistry of the developing gut with antibodies to TN-C, TN-W, TN-R and TN-X. TN-C expression is widespread, while TN-W is found in small patches in a subset of the smooth muscle. TN-R is limited to the autonomic ganglia of the gut, while TN-X is concentrated in the epimysium surrounding bundles of smooth muscle. On the top right is a section of a developing ulna immunostained with antibodies to TN-C and TN-W. Both are strongly expressed in developing bone, with partially overlapping patterns (yellow). On the bottom right is a section though the whisker follicle stem cell niche of an adult mouse. The patterns of TN-C and TN-W expression are more limited in the adult, but they are found in partly overlapping patterns in this stem cell niche. Original images of the developing gut and bone from Meloty-Kapella et al. (40) and adult stem cell niches from Tucker et al. (41) with permission.