Skip to main content
. 2022 Jun 17;12:867271. doi: 10.3389/fonc.2022.867271

Table 1.

Bacterial siderophores used in cancer research.

Siderophore Structure 2D Secreted by Cancer Type Studied
Deferoxamine (DFO) Inline graphic
PubChem Identifier: CID 2973 (25)		 Streptomyces spp Macrophage (34), leukemia (34, 35), breast cancer (34, 36, 37), hepatocellular carcinoma (34, 38–40), gastric cancer (41), neuroblastoma (42, 43), ovarian (36), epidermoid carcinoma (36).
DFCAF (DFO complex) Inline graphic
PubChem Identifier: CID 2973 (25)
Inline graphic
PubChem Identifier: CID 2519 (26)		 Streptomyces spp Cancer stem cells (44).
Desferrithiocin (DFT) Inline graphic
PubChem Identifier: CID 101609363 (27)		 Streptomyces antibioticus DSM Hepatocellular carcinoma (45).
Enterobactin Inline graphic
PubChem Identifier: CID 34231 (28)		 E. coli, Salmonella enterica, Shigella dysenteriae and Klebsiella pneumoniae Monocyte-derived cancer cells (46).
Ferrichrome Inline graphic
PubChem Identifier: CID 644246 (29)		 Lactobacillus casei Gastric (47) and colon cancer (48, 49).
Exochelin-MS Inline graphic
PubChem Identifier: CID 139583168 (30)		 Mycobacterium smegmatis Macrophage, liver cancer, leukemia, breast cancer (34).
Mycobactin S Inline graphic
PubChem Identifier: CID 3083702 (31)		 Mycobacterium smegmatis Macrophage, liver cancer, leukemia, breast cancer (34).
Amamistatin A Inline graphic
PubChem Identifier: CID 135430484 Amamistatin A (32)		 Nocardia asteroids Leukemia, breast, lung, and stomach cancer (50).
Amamistatin B Inline graphic
PubChem Identifier: CID 135438025 Amamistatin B (33)		 Nocardia asteroids Leukemia, breast, lung, and stomach cancer (50).