Figure 1.

Dabigatran does not reduce CNV lesion size but does accelerate repair. Argon laser photocoagulation of Bruch’s membrane was used to generate four laser spots in each eye of the C57BL/6J mice. Mice were analyzed by OCT on day 5 post laser (A) or on days 5, 9, 12, 15 and 23 during the repair paradigm (B). Mice were fed standard or dabigatran chow (~10 mg/kg bodyweight per day) during either the induction phase of the CNV lesion or during the repair phase, starting at day 5. Quantification of the lesion areas using image J analysis on OCT images demonstrate no reduction in CNV size in the short-term paradigm, and an acceleration of repair in dabigatran-fed mice. Data shown are average values ( ± SEM) per lesion and corresponding representative images of CNV lesions are shown.