Figure 7.

Dabigatran affects VEGF expression in repair but not angiogenesis phase of CNV. Equal amounts of RPE/choroid extracts (15 μg/lane) were loaded per lane, probed with antibodies as indicated, and band intensities quantified. Arbitrary values were established based on normalization with GAPDH. Age-matched naive animals without CNV and fed normal mouse chow were compared to those in which CNV was and treated with dabigatran during the angiogenesis and repair phase of CNV. During the induction phase and repair phase of CNV, VEGF levels in the RPE/choroid were elevated; however, dabigatran only affected VEGF levels in the long-term paradigm.