Figure 8.

In repair phase of CNV, dabigatran reduces CTGF expression. Western blot analysis was performed as described in legend for Figure 7 . (A) Dabigatran reduced CTGF in the wound healing paradigm when compared to the control-treated and naïve animals. (B) Complement activation was increased in RPE/choroid of CNV animals when compared to naïve animals. Surprisingly, complement activation was further increased by treatment when compared to PBS controls. Data are expressed as mean ± SEM (n = 3-5 independent samples per condition).