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. 2022 Jun 17;13:916701. doi: 10.3389/fimmu.2022.916701

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Copyright © 2022 Schielke, Zimmermann, Hobelsberger, Steininger, Strunk, Blau, Hernandez, Künzel, Ziegenbalg, Rösing, Beissert, Abraham and Günther

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phagocytosis of oxLDL by monocytes increases with CXCL16 expression. (A) PBMC were incubated with red fluorescing oxLDL for 3 h and subsequently stained for CD14, CD16 and CXCL16 expression. (B) The mean fluorescence intensity (MFI) of CXCL16 and oxLDL is shown. Every psoriasis patient is represented by three dots (n= 15). Colors represent monocyte subsets as defined in Figure 1A , Spearman correlation. (C) oxLDL concentrations in monocytes subsets of healthy controls (unfilled dots; n=5) and patients with psoriasis (filled dots; n=15), mean and SD, unpaired t test. (D) intracellular oxLDL concentrations in monocytes of normal-weight psoriatic patients (unfilled triangles; n=7) and obese patients (filled triangles; n=8), mean and SD, unpaired t test. *p < 0.05; **p < 0.01; ***p < 0.001. ns, not significant.