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. 2022 Jun 17;13:916701. doi: 10.3389/fimmu.2022.916701

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Copyright © 2022 Schielke, Zimmermann, Hobelsberger, Steininger, Strunk, Blau, Hernandez, Künzel, Ziegenbalg, Rösing, Beissert, Abraham and Günther

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ILCs express CXCR6 in patients with psoriasis. (A) T-SNE contour plot presenting the clustering of ILCs in subgroups ILC1 (blue), ILC2 (red) and ILC3 (orange) and their expression of the chemokine receptor CXCR6 (dark blue). There are subgroups of ILC1 and ILC3 expressing the receptor CXCR6. (B) Flow cytometry analysis of MFI of CXCR6 expression on peripheral ILCs of psoriatic patients (n=16) and healthy volunteers (n=16), mean and SD, Welch t test. (C) Correlation of MFI of the receptor CXCR6 and the clinical skin involvment (n= 16), Pearson correlation. (D) Coexpression of chemokine receptors CXCR6, CCR6 and CCR7 among all ILCs. (E) Mean and SD of percentage of CXCR6 expressing ILCs among all ILCs of healthy volunteers (n=16) and psoriatic patients (n=16), Mann-Whitney test. *p < 0.05; **p < 0.01.