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. 2022 Jun 27;15:1157–1173. doi: 10.2147/CCID.S357810

Table 6.

Publications with Similarly Conducted Studies with Regard to Injection Location, Injection Frequency and Method as Well as Cutometry Measurements

Reference # Patients, Location Procedure,
Remarks		 Last Follow up After Last Procedure Substance Used Cutometry Parameter Absolute Measurements: Baseline→Last Follow Up in mm [Change]
Reuther et al 201015 19, cheek 3 sessions 0, 1, 2 months 4 months HA R0 R3 0.29→0.16a [0.13] 0.34→0.2 [0.14]
Hersant et al 201749 31, cheek 3 sessions 0, 1, 2 months
1 i.d. injection+ 1 SkinRoller		 6 months PRP+HA R5 0.45→0.52a
Kerscher et al 201818 42, cheek 4 sessions 0, 1, 2, 3 months controlled, Abstract only 3 months BCS
BCS+HA
BCS
BCS+HA		 R0

R3		 0.40→0.25 [0.15] 0.42→0.31 [0.11] 0.46→0.29 [0.17] 0.47→0.35 [0.12]
Cameli et al 20219 12, cheek 3 sessions 0, 1, 2 months 1 month PRP R5 0.13→0.22a
Kerscher et al 20215 21, cheek 4 sessions 0, 2, 4, 12 weeks 3 months BCS R0 R3 0.34→0.16 [0.18] 0.39→0.20 [0.19]
This publication 95, cheek 4 sessions 0, 2, 4, 6 weeks
multi-center		 48 weeks BCS R0 R3 0.4→0.37 [0.03] 0.45→0.41 [0.04]
Pooled R0 mean R3 mean R5 mean 0.37→0.25 [0.12] 0.42→0.29 [0.13] 0.29→0.3

Notes: aNumbers deducted from graphs. R0: Skin firmness; lower values indicate higher firmness. R3: Skin tiring upon repeated extension; lower values indicate less skin tiring. R5: Net elasticity: ratio of immediate (elastic) retraction to immediate (elastic) extension. Higher values indicate improved elasticity. []: Numbers in brackets are the mean change of a value between baseline and endpoint. Reuther et al used HA for i.d. injections in 19 patients.15 Patients received 3 sessions, one month apart. Hersant et al used HA+PRP in 31 patients. Patients received 3 sessions with a first procedure i.d. injections followed by SkinRoller application on PRP+HA-moistened skin, one month apart. Kerscher et al 18 used BCS vs BCS+HA in a controlled study for i.d. injections in 42 patients. Patients received 4 sessions, one month apart. Cameli et al used PRP for i.d. injections in 12 patients.9 Patients received 3 sessions, one month apart. Kerscher et al used BCS for i.d. injections in 21 patients.5 Patients received 4 sessions at 0, 2, 4, 12 weeks. This study used BCS for i.d. injections in 95 patients. Patients received 4 sessions, 2 weeks apart.