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Aberrant extra mature centrosomes activate caspase-2. During the S/G2 phases of the cell cycle, the centrosome duplicates, but PIDD remains associated with only the mature centrosome. If cytokinesis fails, leading to the formation of a tetraploid cell in the following G1 phase, two mature centrosomes appear in the cell, leading to PIDD–PIDD interaction, recruitment of RAIDD, and activation of caspase-2.
