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Order of events for BAX activation and MOMP. (1) Active BID binds very rapidly to the mitochondrial outer membrane, and then (2) BID binds to the back of BAX, whereupon (3) BAX inserts its α-helix 9 (α9) into the membrane. Then (4) BID binds to the BH groove of BAX, “unlatching” BAX and exposing its BH3, and finally (5) BAX oligomerizes by binding to additional, active BAX molecules, inducing MOMP.
