Figure 30.

Structures of several pore-forming regions of bacterial toxins, compared with that of BAX. Several α-helical pore-forming toxins have a globular domain reminiscent of the BCL-2 core of BAX. The structures are colored blue to red from the amino to the carboxyl terminus, and the putative pore-forming helices are identified by their side-chain sticks. (Top left, PDB1MAZ [Muchmore et al.1996]; top right, PDB 1F0L [Choe et al. 1992]; lower left, PDB 1CII [Winer et al. 1997]; lower right, PDB 2C9K [Boonserm et al. 2006].)