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Mitochondria in NIX-deficient red blood cells. In developing wild-type red blood cells, mitochondria are removed by mitophagy (left), and these organelles are not present in the mature cells. In NIX-deficient mature red cells, mitochondria persist, many showing signs of damage (right). (Image courtesy of Paul A. Ney, MD, St. Jude Children's Research Hospital, Memphis, Tennessee.)
