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Structure of BCL-xL, a globular protein with eight α-helices (numbered 1–8, top). The four BCL-2 homology (BH) regions, BH1–BH4, are also shown. The structure on the bottom shows the groove formed by BH1, BH2, and BH3, bound to a BH3 peptide from BAK (pale blue). (Top, PDB 1MAZ [Muchmore et al. 1996]; bottom, PDB 1BXL [Sattler et al. 1997].)
