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(Left) BH3 regions of several human BH3-only proteins. BH3 regions of BAX, BAK, and BOK are shown for comparison. Note the conserved leucine (L) and aspartate (D) residues (*). Hydrophobic residues (h0–h4) are often (but not always) present where indicated. (Right) The binding of the BH3 region of BIM to MCL-1. The hydrophobic residues and the conserved aspartate interact with the BH groove of MCL-1.
