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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Eur J Endocrinol. 2022 May 12;187(1):49–64. doi: 10.1530/EJE-21-1183

Figure 6. Schematic representation summarizing the major transcriptomic differences in various cell populations between FCTs and SCTs revealed by scRNAseq.

Figure 6.

The tumor cells of FCTs (Micro and Macroadenomas) expressed higher levels of genes involved in prohormonal processing, hormone storage and secretion. Fibroblasts in both functioning corticotroph micro- and macro-adenomas exhibited features of residential fibroblasts that participate in ECM organization, ECM receptor interaction and inflammation. In contrast, SCT tumor cells exhibited reduced expression of genes involved in vesicle biogenesis and granule exocytosis, but increased stromal expression of transcripts of vSMCs and increased expression of genes involved in ECM reorganization, cell motility and migration. WNL: Within normal limits.