Table 1.
Child IXT Symptom Questionnaire Scores by Treatment Group.
| Baseline Visit | 6-Month Visit | 12-Month Visit | 18-Month Visit | |||||
|---|---|---|---|---|---|---|---|---|
| Overminus | Non-overminus | Overminus | Non-overminus | Overminus | Non-overminus | Overminus | Non-overminus | |
| Child IXT Symptoms Score | N = 181 | N = 183 | N = 182 | N = 167 | N = 180 | N = 165 | N = 174 | N = 153 |
| Mean (SD) | 34.5 (17.2) | 35.3 (17.4) | 28.8 (16.9) | 31.1 (16.6) | 28.4 (15.3) | 28.1 (16.2) | 28.6 (15.3) | 28.8 (16.4) |
| Median (IQR) |
37.4 (25.7, 46.1) |
37.4 (25.7, 46.1) |
32.2 (15.7, 37.4) |
32.2 (15.7, 42.0) |
32.2 (15.7, 39.7) |
32.2 (15.7, 37.4) |
32.2 (15.7, 37.4) |
32.2 (15.7, 42.0) |
| Range | 0 to 99.9 | 0 to 99.9 | 0 to 99.9 | 0 to 68.1 | 0 to 62.9 | 0 to 74.5 | 0 to 58.4 | 0 to 74.5 |
| Difference in means (95% CI)a | n/ab | −3.05 (−6.18, 0.09) | 0.24 (−2.93, 3.42) | −0.45 (−3.95, 3.04) | ||||
| P-valuea | n/ab | 0.17 | 0.88 | 0.88 | ||||
| Change from Baseline | N = 172 | N = 163 | N = 171 | N = 161 | N = 162 | N = 148 | ||
| Mean (SD) | n/a | n/a | −6.5 (16.7) | −4.0 (18.9) | −6.2 (17.3) | −7.1 (20.5) | −5.9 (20.8) | −5.6 (20.9) |
IXT = intermittent exotropia; SD = standard deviation; IQR = interquartile range; CI = confidence interval
a
Treatment group differences (mean and 95% CI) in Rasch 0–100 scores were estimated at 6, 12, and 18 months using an ANCOVA model, adjusted for the baseline value of the respective score. P-values were calculated by running the same models on the Logit scores. P-values were adjusted to control the false discovery rate at a probability level of 5%.
b
Statistical comparison of scores was not done at baseline.