Fig 2. Both monosomies and trisomies decrease cellular fitness.

A. Spearman correlation between the total number of imbalanced, gained and lost coding genes per clone and proliferation rates as measured in Fig 1A. Error bars indicate standard deviation. Light green panels indicate the preferred model. B. Spearman correlation between the number of imbalanced, gained and lost coding genes and the level of CIN as percentage of total number of anaphases as determined in Fig 1B. Error bars indicate standard deviation. Light green panels indicate the preferred model. C. Missegregation rates described in A, classified in three different categories: euploid clones, clones harboring only monosomies and clones harboring trisomies (sometimes with monosomies in the background). Lines show the mean; error bars indicate standard deviation. The Mann-Whitney U statistical test was used to compare differences in CIN between groups.