Fig 2. The relationship between disrupted H3K4me1/3, regional observed-to-expected CpG ratio, and gene expression in Kmt2a-deficient mice.

(A) The percentage of disrupted H3K4me1 peaks (left) and H3K4me3 peaks (right), stratified based on the observed-to-expected CpG ratio of the underlying peak sequence. (B) Scatterplot of the log₂ fold change of H3K4me1 peaks against the log₂ fold change of H3K4me3 peaks at promoters (+/-1kb from the TSS) that harbor peaks for both marks. (C) The percentage of differentially expressed genes, stratified based on the p-value of associated promoter peaks (+/- 1kb from the TSS) from the differential H3K4me1 analysis (left) and H3K4me3 (right) analysis. (D) Scatterplot of the log₂ fold change of H3K4me1 peaks (left) and H3K4me3 (right) against the log₂ fold change of gene expression of the downstream gene. Each point corresponds to a gene-promoter pair. In cases where multiple peaks were present at the same promoter, the average log₂ fold change was computed.