Table 4.
Docking Results for Doxorubicin with Unbound Breast Cancer Receptors and hGH Fragment 176–191 Peptide-Bound Breast Cancer Receptors
| Breast Cancer Biomarkers Receptor | Receptor vs Doxorubicin | Receptor + Peptide vs Doxorubicin | ||
|---|---|---|---|---|
| Final Intermolecular Energy (Kcal/mol) | Inhibition Constant (Ki) | Final Intermolecular Energy (Kcal/mol) | Inhibition Constant (Ki) | |
| Estrogen receptor (PDB:1QKU) | −2.77 | NA | −1.58 | NA |
| Progesterone receptor (PDB: 2OVH) | −10.09 | 139.01 mM | −11.31 | 14.41 mM |
| Human epidermal growth factor receptor (PDB:3GOP) | −6.55 | 39.10 mM | −8.02 | 6.02 mM |
| Mind bomb (Mib) Protein (PDB:4TSE) | −5.76 | 158.20 mM | −6.11 | 74.65 mM |
| Ki-67 (PDB:5J28) | −7.62 | 2.81 mM | −6.84 | 20.54 mM |