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. 2022 Jun 17;12:901922. doi: 10.3389/fonc.2022.901922

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Copyright © 2022 Ren, He, Zhao and Ma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VB promotes M1 polarization in OC tissues through inhibiting CCN1-mediated AKT/NF-κB pathway. (A) The relative mRNA expression of CCN1 in tumour tissue was detected by RT-qPCR. (B) The CCN1 protein expression was detected in tumour tissue by immunohistochemistry. (C) The protein expression levels of CCN1, p-AKT/AKT, and p-p65/p65 were detected by western blotting in tumour tissue. (D) The ratio of CD86⁺/CD206⁺ in tumour tissues was measured by flow cytometry. Tumour tissue was removed from tumour xenograft model mice subcutaneously injected with A2780 cells. Each treatment was replicated three times. Error bars represent mean ± SD; ^* P < 0.05and ^** P < 0.01.