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Preterm HIE has much higher creatine kinase brain isoenzyme (CK-BB) than term HIE (Talvik et al., 1995). CK-BB is a weak biomarker for the severity of neurological deficits at 12 months of age if done at 2 days (score 44) but a strong biomarker if done at 5 days of life (score 732)
