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. 2022 Jun 15;14:909222. doi: 10.3389/fnagi.2022.909222

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Copyright © 2022 Xie, Pei, Shan, Xiao, Zhou, Huang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A,B) The transfection efficiency of pCDH-PTGS2 and si-PTGS2 was detected by western blot. (C) The effects of PTGS2 knockdown or overexpression on the vitality of AD model cells (Aβ_25–35-treated SH-SY5Y cells) measured using the CCK-8 assay. (D,E) The effects of PTGS2 knockdown or overexpression on the proliferation of AD model cells (Aβ_25–35-treated SH-SY5Y cells) measured using the soft agar assay. Scales: 10 × 40. (F,G) The effects of PTGS2 knockdown or overexpression on the migration of AD model cells (Aβ_25–35-treated SH-SY5Y cells) measured using the wound healing assay. Scales: 10 × 10. The data are shown as the mean ± standard deviation. The horizontal line indicates the comparison between groups at both ends, and the non-horizontal line indicates the comparison with the control group. AD: Alzheimer’s disease. ^***p < 0.001; ^**p < 0.01; *p < 0.01.