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. 2022 Jun 15;14:909222. doi: 10.3389/fnagi.2022.909222

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Copyright © 2022 Xie, Pei, Shan, Xiao, Zhou, Huang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Venn diagram shows the overlap between AD related Chinese herbs and PTGS related Chinese herbs. (B) Network of AD related components in HUANGQIN and PTGS2 targeted components in HUANGQIN. (C) The effects of different concentrations baicalein on the vitality of AD model cells (Aβ_25–35-treated SH-SY5Y cells) measured using the CCK-8 assay. (D) EC₅₀ fitting curve of baicalein in AD model cells (Aβ_25–35-treated SH-SY5Y cells). (E) The effect of baicalein on the expression of PTGS2 by qPCR in AD model cells (Aβ_25–35-treated SH-SY5Y cells). AD, Alzheimer’s disease. The expression level of GAPDH was used as an internal reference for PTGS2. The data are shown as the mean ± standard deviation. The horizontal line indicates the comparison between groups at both ends, and the non-horizontal line indicates the comparison with the control group. ^***p < 0.001; *p < 0.05.