Figure 4.

Immunofluorescent analysis of α-cell regression to the progenitor state in the pancreatic tissues of T2D mice treated with GCGR mAb or IgG control for 4 weeks

(A–C) Representative photograph showing β-gal (α-cell lineage-tracing marker)⁺Ngn3⁺ cells (A), β-gal⁺Glut2⁺ cells (B), and β-gal⁺Pdx1⁺ cells (C) in α-cell lineage-tracing T2D mice that were induced by HFD + STZ. The arrows indicate co-labeled cells. The cells in the small box are enlarged at the right of the image. Scale bar = 50 μm. See also Figures S5.