Fig. 4.
Effects of filgotinib on the Cmax and AUClast of levonorgestrel, ethinyl estradiol, midazolam, methotrexate, atorvastatin, pravastatin, rosuvastatin, and metformin (geometric mean of the point estimate with 90% confidence intervals). Geometric mean ratio for AUC∞ is shown when the victim drug was given as a single dose; geometric mean ratio of AUCτ is shown when the victim drug was given as multiple doses. AUC∞ area under the plasma concentration–time curve from time zero to infinity, AUCτ area under the plasma concentration–time curve during a dosage interval (τ), Cmax maximum (peak) plasma drug concentration