Fig. 5.

Simulated steady-state inhibition of pSTAT1 with 90% confidence intervals. The 90% confidence intervals shown represent parameter uncertainty and are based on 1000 replicates of the pharmacokinetic and pharmacokinetic/pharmacodynamic models describing STAT1 inhibition [13]. Gray dotted and gray dashed curves show model-predicted filgotinib and metabolite plasma concentrations, respectively (common arbitrary units). BID twice daily, pSTAT phosphorylated signal transducer and activator of transcription protein, QD once daily. Figure

adapted from Namour et al. [13], distributed under the terms of a Creative Commons Non-Commercial 4.0 International (CC BY-NC 4.0) license. © 2015, the author(s)