Table 1.
Pharmacokinetics of filgotinib and its primary metabolite after a single oral dose of filgotinib in healthy subjects [13]
| Filgotinib dose | Filgotinib | Primary metabolite | ||||||
|---|---|---|---|---|---|---|---|---|
| Cmax, µg/mL | tmax, h | AUC∞, µg·h/mL | t1/2, h | Cmax, µg/mL | tmax, h | AUC∞, µg·h/mL | t1/2, h | |
| 100 mg (n = 6) | 0.57 (33.9) | 2.00 (0.500–3.00) | 1.74 (14.3)a | 4.91 (11.5) a | 0.96 (10.0) | 5.00 (5.00–5.00) | 30.2 (17.2) | 22.5 (13.0) |
| 200 mg (n = 6) | 1.16 (24.3) | 3.00 (1.00–3.00) | 4.84 (12.3)a | 5.68 (39.6)a | 2.29 (18.7) | 5.00 (3.00–8.00) | 63.8 (22.2) | 20.0 (19.6) |
Estimates are arithmetic means (CV%) except median (range) for tmax
AUC∞ area under the plasma concentration–time curve from time zero to infinity, Cmax maximum (peak) plasma concentration, CV coefficient of variation, t½ apparent terminal half-life, tmax time to reach Cmax following drug administration
an = 4