Fig. 1.

Goodness of fit of the final model including observations vs individual predictions (a), observations vs population predictions (b), conditional weighted residuals (CWRES) vs population predictions (c), and CWRES vs time (d). The solid red line is the LOESS regression of the scatter plot; the black dashed line is the unity line; the dashed red line represents the 95%, 50%, and 5% percentile of the data