Table 2.
Parameter estimates of the base model and the final model
| Base model | Final model | |
|---|---|---|
| ∆OFV | – | −61.91 |
| Fixed-effect parameters | ||
| CL (L/h) | 15.2 (5%) | 14.7 (4.1%) |
| V1 (L) | 61.7 (7.1%) | 61.2 (7.1%) |
| Q (L/h) | 44.3 (6.6%) | 44.9 (6.7%) |
| V2 (L) | 72.1 (5.9%) | 71.6 (6%) |
| eGFR on CL (linear) | – | 0.008 (12%) |
| Random-effect parameters | ||
| IIVCL | 58.7% (14.2%) [7.6%] | 47.2% (14.7%) [8.5%] |
| IIVV1 | 62.1% (19.7%) [25%] | 61.1% (19.7%) [25.2%] |
| IIVV2 | 46.5% (23%) [36%] | 46.8% (21.8%) [35%] |
| IOVCL | 16% (32.9%) [64.8%] | 13.6% (38.7%) [65.2%] |
| Residual error | ||
| AddStudy1 | 0.149 mg/L (27.7%) | 0.151 mg/L (27.1%) |
| PropStudy1 | 17.5% (9.5%) | 17.5% (9.5%) |
| PropStudy2 | 13.8% (3.6%) | 13.7% (3.6%) |
| PropStudy3 | 24.2% (5.2%) | 24.5% (5.1%) |
The relative standard error is shown within the parenthesis and the shrinkage is shown within the square bracket
Add additive residual error, CL clearance, eGFR estimated glomerular filtration rate using the MDRD equation, IIV inter-individual variability, IOV inter-occasion variability, OFV objective function value, Prop proportional residual error, Q inter-compartmental clearance, V1 central volume of distribution, V2 peripheral volume of distribution