Table 3.
Comparison of parameters’ posterior distributions between studies
| Parameter | Posterior mean | Posterior inter-individual variability | ||||||
|---|---|---|---|---|---|---|---|---|
| Study 1 | Study 2 | Study 3 | CV (%) | Study 1 (%) | Study 2 (%) | Study 3 (%) | CV (%) | |
| CL | 16.6 L/h | 16 L/h | 12.6 L/h | 14.3 | 54 | 35 | 38 | 24.1 |
| V1 | 65 L | 59.1 L | 55.7 L | 7.9 | 55 | 54 | 48 | 7.2 |
| V2 | 75.8 L | 70.1 L | 63.7 L | 8.7 | 35 | 32 | 44 | 16.9 |
CL clearance, CV coefficient of variation, calculated for the posterior mean and posterior inter-individual variability of three studies, V1 central volume of distribution, V2 peripheral volume of distribution
For each patient, 100 random samples were drawn from the posterior distribution of each random-effect parameter