| A population pharmacokinetic model of ciprofloxacin was developed based on pooled data from three intensive care unit data sets, containing in total 140 intensive care unit patients and 1094 concentration–time samples. |
| Despite the large amount of data, only bodyweight and renal function were associated with pharmacokinetic parameters of ciprofloxacin still leaving much inter-individual variability unexplained by commonly deployed covariates. |
| A simple dose strategy of ciprofloxacin suitable for all intensive care unit patients remains challenging and dose individualization may be needed. |
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