Fig. 2.

VE-cadherin trafficking regulation. VE-Cadherin (VE-Cad) trafficking from the Golgi apparatus to the plasma membrane is potentially aided by AP1, AP2, golgin97 and golgin245. Post-Golgi transporter Rab8 is positioned at the trans-Golgi network, where it may be involved in trafficking to the plasma membrane. At the plasma membrane exocytic machinery, such as vesicular (v)-SNARE’s and tethering (t)-SNARE’s play a role in vesicle capture and docking. Once plugged into the plasma membrane, VE-Cad is maintained in a recycling loop via Rab11a and p120. Asymmetric localization of VE-Cad is thought to involve a PACSIN/EHD4/MICAL-L1 complex. VE-Cad endocytosis may be regulated by Rab5-mediated shuttling to the CORVET and HOPS complex prior to lysosomal degradation. Rab35 and Rab10 act as either apical or basolateral determinants, respectively. Table lists proteins depicted in figure with corresponding function